In the derivation of the MichaelisMenten equation based on the following reaction k1 k2 E S ES E P k_1 the Michaelis constant KM is defined under the approximation Under the approximation, the Michaelis constant KM is an estimation oft Enzymesubstrate binding affinity Ks (=k_7 /k7 )Looking at the equation, one can readily see that the velocity of the reaction, V, is dependent on the substrate concentration, SIn fact, the MichaelisMenten equation is a rational functionAs rational functions can be difficult to work with graphically, the MichaelisMenten equation can be transformed into a linear equation by taking the reciprocal of both sides as, The MichaelisMenten equation was derived by Leonor Michaelis and his graduate student Maud Menten in 1913, based on work by Victor Henri, and is applicable only to simple enzyme kinetics in which there is only one substrate that is changed immediately to a product during the reaction without forming any intermediate compound, the enzyme in question shows
Derivation Of Michaelis Menten Kinetics Youtube
